Interactions : אינטראקציות

4.5 Interaction with other medicinal products and other forms of interaction
Oral metronidazole has been associated with a disulfiram-like reaction in combination with alcohol. Acute psychotic reactions and confusion have occurred during concomitant use of disulfiram with oral metronidazole. At the low serum concentrations which result from the use of Zidoval 7.5 mg/g vaginal gel , the possibility of similar reactions is unlikely although cannot be excluded.Oral metronidazole has been shown to increase the plasma concentrations of warfarin and other coumarin anticoagulants resulting in a prolongation of prothrombin time.
The effect of topical metronidazole on prothrombin time is unknown. It has also been shown to increase the plasma concentrations of lithium, cyclosporin and 5- fluorouracil. Similar effects after vaginal administration of metronidazole are not expected due to the low plasma concentrations but cannot be completely ruled out.
Metronidazole may interfere with certain types of determination of serum chemistry values, such as aspartate aminotransferase (AST, SGOT), alanine aminotransferase (ALT, SGPT), lactic dehydrogenase (LDH), triglycerides and hexokinase glucose.
Values of zero may be observed.