Posology : מינונים

4.2 Posology and method of administration
Posology
The recommended dosage is 10 mg orally once a day at least 15 minutes before meals; the dose may be increased to 20 mg depending on the individual patient's response.
Dose titration should be gradual, because it may take about 2 weeks before the maximal antihypertensive effect is apparent.
Some individuals, not adequately controlled on a single antihypertensive agent, may benefit from the addition of Vasodip to therapy with a beta-adrenoceptor blocking drug (atenolol), a diuretic (hydrochlorothiazide) or an angiotensin converting enzyme inhibitor (captopril or enalapril).
Since the dose-response curve is steep with a plateau at doses between 20-30 mg, it is unlikely that efficacy will be improved by higher doses; whereas side effects may increase.
Elderly patients: Although the pharmacokinetic data and clinical experience suggest that no adjustment of the daily dosage is required, special care should be exercised when initiating treatment in the elderly.
Paediatric population: The safety and efficacy of Vasodip in children aged up to 18 years have not been established.
No data are available.
Patients with renal or hepatic impairment: special care should be exercised when treatment is commenced in patients with mild to moderate renal or hepatic dysfunction. Although the usually recommended dose schedule may be tolerated by these subgroups, an increase in dose to 20 mg daily must be approached with caution.The antihypertensive effect may be enhanced in patients with hepatic impairment and consequently an adjustment of the dosage should be considered.
Vasodip is contraindicated in patients with severe hepatic impairment or in patients with severe renal impairment (GFR  30 ml/min) (see sectons 4.3 and 4.4).
Method of administration
Precautions to be taken before handling or administering the medicinal product: -   Treatment should be preferably administered in the morning at least 15 minutes before a meal.
-   This product should not be administered with grapefruit juice (see section 4.3 and 4.5).