Posology : מינונים

4.2 Posology and method of administration
The dose of verapamil hydrochloride should be adjusted individually according to the severity of the condition. Long-term clinical experience demonstrates that the average dose for all indications is in the dose range of 240 mg-360 mg.

The maximum daily dose should not exceed 480 mg for long-term treatment; in the case of short-term treatment, a higher dose may be administered.

Verapamil treatment should not be stopped abruptly. Gradual dose reduction is recommended.

The pharmaceutical form with a concentration of 40 mg of verapamil hydrochloride is recommended for patients who require low doses (e.g. patients with liver disease and elderly patients).

For patients requiring higher doses (360 to 480 mg of verapamil hydrochloride per day), other formulations with appropriate concentrations of the active substance should be administered.

Adolescents and children
Adolescents aged 14 and above with body weight over 50 kg

Coronary heart disease, paroxysmal supraventricular tachycardia, atrial fibrillation and atrial flutter.
The recommended dose is 120-480 mg verapamil hydrochloride, given in 3-4 doses.

Hypertension
The recommended dose is 120-480 mg verapamil hydrochloride, taken in 3 doses.

Children aged 6-14 years (only for heart rhythm disorders)
The recommended dose is 80-360 mg verapamil hydrochloride, taken in 2-4 doses.
Liver failure
Depending on the severity of the liver damage, the metabolism of verapamil hydrochloride is delayed, which intensifies its effects. Therefore, in this group of patients the dose should be adjusted and treatment should be initiated with the minimum effective dose.

Administration method
The tablets should be swallowed whole, with liquid, preferably during a meal or immediately after a meal.
For ease of swallowing, the tablets can be broken into two and the two halves swallowed as one dose.