Contraindications : התוויות נגד

Contraindications: Septanest (articaine hydrochloride) is contraindicated in patients with known allergies to dental anaesthetics. Septanest is also contraindicated in patients with sepsis near the proposed injection site, severe shock, paroxysmal tachycardia, frequent arrhythmia, neurological disease, severe hypertension or in patients with asthma who may have bronchospastic allergic reactions induced by sulphites.

Since Septanest contains epinephrine the caution required of any vasoconstrictor drug is in order.
Septanest is also contraindicated in patients with:
- Paroxysmal tachycardia or high-frequency, continuous arrhythmia ;
- Pronounced coronary insufficiency ;
- Severe hypertension (high blood pressure) ;
- Thyrotoxicosis (hyperactivity of the thyroid) ;
- Narrow-angle glaucoma ;
- Decompensated diabetic metabolic condition ;
- Pheochromocytoma ;
- Cerebrovascular insufficiency.

Warnings: Septanest, along with other local anaesthetics, is capable of producing methaemoglobinaemia. The clinical signs of methaemoglobinaemia are cyanosis of the nail beds and lips, fatigue and weakness. If methaemoglobinaemia does not respond to administration of oxygen, administration of methylene blue intravenously 1 to 2 mg/kg body weight over a 5 minute period is recommended.

Septanest (articaine hydrochloride) must be used with particular caution in the event of: - Severe impairment to the renal or hepatic function ;
- Angina pectoris (tightness in the chest) ;
- Arteriosclerosis (vascular sclerosis) ;
- Injection into an inflamed (infected) area ;
- Considerably impaired blood coagulation ;
- Epilepsy ;
- Impaired respiratory function.

Septanest contains sulphites which can cause or aggravate anaphylactic-type reactions.

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Intravascular injection is strictly contraindicated : therefore, it is imperative to ensure that the needle being used for the injection does not go into a vessel.

Toxic reactions may occur in the case of overdosage or accidental intravenous injection.