Posology : מינונים

4.2   Posology and method of administration
Posology:

The mode of therapy, frequency of treatment, exchange volume, duration of dwell and length of dialysis should be selected by the attending physician.

Adults

Patients on continuous ambulatory peritoneal dialysis (CAPD) typically perform 4 cycles per day (24 hours). Patients on automated peritoneal dialysis (APD) typically perform 4-5 cycles at night and up to 2 cycles during the day. The fill volume depends on body size, usually from 2.0 to 2.5 litres.

Paediatric population (i.e., newborn to 18 years of age)

800 to 1400 ml/m2 per cycle up to a maximum amount of 2000 ml, as tolerated, is recommended. Fill volumes of 500 to 1000 ml/m2 are recommended in children less than 2 years of age.

As the patient’s body weight becomes closer to the ideal dry weight, lowering the glucose concentration of Dianeal PD4 is recommended.

Dianeal PD4 3.86% glucose-containing solution is a high osmotic pressure fluid and using it alone may cause dehydration (See section 4.4).

To avoid the risk of severe dehydration, hypovolaemia and to minimise the loss of proteins, it is advisable to select the peritoneal dialysis solution with the lowest osmolarity consistent with fluid removal requirements for each exchange.

Method of Administration

Precautions to be taken before handling or administering the medicinal product 
Dianeal PD4 is intended for intraperitoneal administration only. Not for intravenous administration.

Peritoneal dialysis solutions may be warmed to 37°C to enhance patient comfort.
However, only dry heat (for example, heating pad, warming plate) should be used.
Solutions should not be heated in water due to an increased risk of contamination.
Solutions should not be heated in a microwave oven due to the potential for damage to the container and patient injury or discomfort.
Aseptic technique must be employed throughout the peritoneal dialysis procedure.
Do not administer if the solution is discoloured, cloudy, contains particulate matter or shows evidence of leakage, or if seals are not intact.

The drained fluid should be inspected for the presence of fibrin or cloudiness, which may indicate the presence of peritonitis.

For single use only.