Overdose : מינון יתר

4.9 Overdose

Symptoms
Overdose may cause vasomotor instability with nausea, vomiting, weakness, central nervous system depression, flushing, lightheadedness, stroke, heart rhythm disorders and tachycardia.
Acute overdose is expressed in hypotension and cardiorespiratory depression.

Treatment
At the first signs of overdose, treatment should be discontinued and the treating physician should be notified who will decide whether hospitalization is required.

In case of overdose, symptomatic treatment consists of supporting patient ventilation and blood circulation.
Vital signs (blood gas and cardiac conduction) should be monitored.
In case of seizures, parenteral administration of diazepam, phenytoin or phenobarbital will be started.
In case of refractory seizures, thiopental and halothane may be used to induce general anesthesia and a neuromuscular blocking agent may be used to cause paralysis.
To treat hypotension, administer intravenous fluids and, if necessary, sympathomimetic agents (norepinephrine).
For the treatment of heart disorders, intravenous administration of calcium gluconate together with ECG monitoring may be helpful.