Pharmacological properties : תכונות פרמקולוגיות

Pharmacodynamic Properties

5.1 Pharmacodynamic properties
Pharmacotherapeutic group: Antiinfective for treatment of acne.
ATC code: D10A F01
Zindaclin 1% Gel contains clindamycin phosphate which is hydrolyzed in the skin to the active constituent clindamycin. Clindamycin is a lincosamide antibiotic with primarily bacteriostataic action against Gram positive aerobes and wide range of anaerobic bacteria.
When clindamycin phosphate is applied cutaneously, clindamycin is found in comedone samples at sufficient levels to be active against most strains of Propionibacterium (P. acnes). It thus reduces the number of surface and follicular P.
acnes, one of the etiological factors of the disease.

As with all antibiotics, the long-term use of cutaneous clindamycin may lead to resistance.

Pharmacokinetic Properties

5.2 Pharmacokinetics properties
In Zindaclin 1% Gel, clindamycin phosphate binds with zinc to form a complex in a formulation which result in a reduced extent of absorption. A study with Zindaclin 1% Gel in vitro with human skin has shown the penetration of radiolabelled clindamycin phosphate from the Zindaclin 1% Gel formulation to be less than 5% of the applied dose.
When applied topically to patients with acne at the maximum anticipated clinical dose, a very small amount (median less than 2ng/ml) of clindamycin was measured in the plasma.