Special Warning : אזהרת שימוש

4.4 Special warnings and precautions for use

The product contains approximately 20% ethanol. Each gram contains approximately 0.2 gram alcohol.
Do not light a cigarette or come in contact with an open flame until the product has been completely dried off.

Oral and parenteral clindamycin, as well as most other antibiotics, have been associated with severe pseudomembranous colitis. Topical clindamycin has very rarely been associated with pseudomembranous colitis; however if diarrhea occurs the product should be discontinued immediately.

Studies indicate a toxin(s) produced by Clostridium difficile is the major cause of antibiotic-associated colitis. Colitis is usually characterized by severe persistent diarrhea and abdominal cramps. Should antibiotic associated colitis occur, appropriate diagnostic and therapeutics measures (Such as vancomycin treatment) should be taken immediately. Responses may not be seen for 4-6 weeks.

Although the risk of systemic absorption following the administration of Zindaclin 1% Gel is low, the potential for the development of gastrointestinal adverse effects should be taken into account when considering treatment in patients with a previous history of antibiotic-associated colitis, enteritis, ulcerative colitis or Crohn’s disease.

Cross resistance may occur with other antibiotics such as lincomycin and erythromycin.

Contact with the eyes or the mucous membranes of the nose and mouth should be avoided. In the event of accidental contact with the eyes or mucous membranes bathe the affected area with copious amounts of cool water.

Prolonged use of clindamycin may cause resistance and/or overgrowth of non susceptible bacteria or fungi although this is a rare occurrence.
Zindaclin 1% Gel contains propylene glycol. May cause skin irritation.
The irritation potential of Zindaclin 1% Gel may be increased if the product is used under occlusion.

Effects on Driving

4.7 Effects on ability to drive and use machines

None.