Posology : מינונים

4.2 Posology and method of administration

Posology: single and daily dosages
Sterility in females.
The dosage of hMG for the induction of follicle growth in normo- or hypogonadotropic woman varies according to the individual. The amount depends on ovarian reaction and should be checked by ultrasound examinations of the ovaries and measuring estradiol levels. If the hMG dosage is too high for the treated individual, multiple uni- and bilateral follicle growth can occur.
hMG is administered intramuscularly or subcutaneously and in general, the therapy is begun with a daily dosage corresponding to 75 – 150 IU FSH.
If the ovaries do not respond, the dosage can slowly be increased until a rise in estradiol secretion and follicle growth is evident. Treatment with the same dosage of hMG continues until pre-ovulatory estradiol serum level is attained.
If the level rises too quickly, the dosage should be reduced. To induce ovulation, 5,000 or 10,000 IU hCG are injected IM to 2 days after the last hMG administration.
Note: after a hMG dosage too high for corresponding individual has been administered, the following hCG administration can cause an unintentional hyperstimulation of the ovaries.
Sterility in males.
Initially, 3 x 1,000 to 3,000 hCG a week are administered until a normal testosterone serum level is reached.
Children:
Not recommended for use in children.
Elderly:
Not recommended for use in the elderly.
Then, an additional dose of hMG (3 x 75 to 150 IU FSH + 75 to 150 IU LH ) per week is administered IM for a few months.
Method of Administration:

Menopur® is administered by intramuscular or subcutaneous injection.