Interactions : אינטראקציות

4.5 Interactions with other medicinal products and other forms of interaction
Caesarean section:
Interaction resulting from concomitant use is not recommended.
Immediately after extraction of the infant, 5 IU can be injected slowly I.V.
Prostaglandins and their analogues
Prevention of postpartum uterine haemorrhage:
The usual dose is 5 IU slowly I.V. after delivery of the placenta. In women given Oxytocin       Prostaglandins and their analogues facilitate contraction of the myometrium, hence oxytocin can potentiate the uterine action of prostaglandins and analogues and vice PANPHARMA for induction or enhancement of labour, the infusion should be continued at an         versa (see section 4.3 Contraindications).
increased rate during the third stage of labour and for the next few hours thereafter.
Drugs prolonging the QT interval
Treatment of postpartum uterine haemorrhage:
Oxytocin should be considered as potentially arrhythmogenic, particularly in patients with 5-10 IU I.M. or 5 IU slowly I.V., followed in severe cases by intravenous infusion of a          other risk factors for torsades de pointes, such as drugs, w hi c h prolong the QT solution containing 5-20 IU of oxytocin in 500 ml of a non-hydrating diluent, run at the rate necessary to control uterine atony.                                                         interval or in patients with history of long QT syndrome (see section 4.4 Special warnings and precautions for use).
Due to the antidiuretic effect of Oxytocin PANPHARMA which suppresses urine excretion (see section 4.8 Undesirable effects), the following measures should be observed when            Interactions to be considered administering Oxytocin PANPHARMA at high doses:                                                  Inhalation anaesthetics An isotonic sodium chloride solution (not glucose) should be used and the infused volume         Inhalation anaesthetics (e.g., cyclopropane, halothane, sevoflurane, desflurane) have a of fluid must be kept low. At the same time, oral fluid intake should be restricted and the      relaxing effect on the uterus and produce a notable inhibition of uterine tone, and thereby fluid balance monitored. If an electrolyte imbalance is suspected, serum electrolytes must       may diminish the uterotonic effect of oxytocin. Their concurrent use with oxytocin has be monitored.                                                                                    also been reported to cause cardiac rhythm disturbances.
Incomplete, inevitable, or missed abortion:                                                      Vasoconstrictors/Sympathomimetics 5 IU I.M. or slowly I.V., if necessary followed by intravenous infusion at a rate of 20-40       Oxytocin may enhance the vasopressor effects of vasoconstrictors and sympathomimetics, mU/min or higher.                                                                                even those contained in local anaesthetics.
4.3 Contraindications                                                                            Caudal anaesthetics
• Hypersensitivity to the active substance or to any of the excipients listed in section         When given during or after caudal block anaesthesia, oxytocin may potentiate the pressor
6.1.                                                                                           effect of sympathomimetic vasoconstrictor agents.
• Hypertonic uterine contractions, mechanical obstruction to delivery, foetal distress.