Interactions : אינטראקציות

4.5   Interaction with other medicinal products and other forms of interaction

Clinical studies have demonstrated that Priorix Tetra can be given simultaneously with any of the following monovalent or combination vaccines [including hexavalent vaccines (DTPa-HBV-IPV/Hib)]: diphtheria-tetanus-acellular pertussis vaccine (DTPa), Haemophilus influenzae type b vaccine (Hib), inactivated polio vaccine (IPV), hepatitis B vaccine (HBV), meningococcal serogroup B vaccine (MenB), meningococcal serogroup C conjugate vaccine (MenC), meningococcal serogroups A, C, W- 135 and Y conjugate vaccine (MenACWY) and 10-valent pneumococcal conjugate vaccine.

Due to an increased risk of fever, tenderness at the injection site, change in eating habits and irritability when Bexsero was co-administered with Priorix-Tetra, separate vaccinations can be considered when possible.

There are currently insufficient data to support the use of Priorix Tetra with any other vaccines.
If Priorix Tetra is to be given at the same time as another injectable vaccine, the vaccines should always be administered at different injection sites.

Serological testing
If tuberculin testing has to be done it should be carried out before or simultaneously with vaccination since it has been reported that combined measles, mumps and rubella vaccines may cause a temporary depression of tuberculin skin sensitivity. As this anergy may last up to a maximum of 6 weeks, tuberculin testing should not be performed within that period after vaccination to avoid false negative results.

In subjects who have received human gammaglobulins or a blood transfusion, vaccination should be delayed for at least three months because of the likelihood of vaccine failure due to passively acquired antibodies.

Vaccine recipients should avoid use of salicylates for 6 weeks after each vaccination with Priorix Tetra (see section 4.4).