Quest for the right Drug
ורומאל תמיסה VERRUMAL SOLUTION (FLUOROURACIL, SALICYLIC ACID)
צורת מתן:
חיצוני : TOPICAL
צורת מינון:
תמיסה : SOLUTION
עלון לרופא
מינוניםPosology התוויות
Indications תופעות לוואי
Adverse reactions התוויות נגד
Contraindications אינטראקציות
Interactions מינון יתר
Overdose הריון/הנקה
Pregnancy & Lactation אוכלוסיות מיוחדות
Special populations תכונות פרמקולוגיות
Pharmacological properties מידע רוקחי
Pharmaceutical particulars אזהרת שימוש
Special Warning עלון לרופא
Physicians Leaflet
Interactions : אינטראקציות
4.5 Interaction with other medicinal products and other forms of interaction
The dihydropyrimidine dehydrogenase (DPD) enzyme plays an important part in the fluorouracil degradation. Antiviral nucleoside analogues such as Brivudine and Sorivudine may lead to a drastic increase in plasma concentrations of fluorouracil or other fluoropyrimidines and therefore to an associated rise in toxicity.
For this reason, a time interval of at least 4 weeks should be adhered to between the use of fluorouracil and Brivudine, Sorivudine and analogues.
In the event of nucleoside analogues, such as Brivudine and Sorivudine, accidentally being administered to patients who are being treated with fluorouracil, effective measures should be taken to reduce fluorouracil toxicity. Admission to hospital is also advised, as necessary. All measures should be taken to prevent systemic infection and dehydration.
With the simultaneous administration of phenytoin and systemic fluorouracil, an increase in the plasma concentration of phenytoin was reported that led to phenytoin intoxication symptoms (see Section 4.4).
Resorbed salicylic acid may interact with methotrexate and sulphonylureas.
מידע נוסף
