Special Warning : אזהרת שימוש

4.4 Special warnings and precautions for use

Verrumal Solution contains the cytostatic 5-fluorouracil.
The dihydropyrimidine dehydrogenase (DPD) enzyme plays an important part in the fluorouracil degrada- tion. An inhibition, deficiency or reduced activity of this enzyme can result in fluorouracil accumulation.
However, as percutaneous absorption of fluorouracil is negligible when Verrumal is administered as per the approved prescribing information, no differences in the safety profile of Verrumal are expected in this sub- population and no dose adjustments are considered necessary.

Patients who are taking phenytoin at the same time as fluorouracil should regularly be examined for ele- vated phenytoin plasma levels.

If areas of skin with thin epidermis are affected by warts, Verrumal Solution shall be applied less fre- quently and checked more often during treatment, as scars may form due to the salicylic acid contained in Verrumal Solution severely softening the corneous layer.

With warts that are very prone to cornification, it is sometimes appropriate to pretreat them with a salicylic acid plaster.

Verrumal Solution should not be used on bleeding lesions.

Strict medical supervision is required with patients with somatosensory disorders (e.g. with Diabetes melli- tus).

Close the bottle tightly after every use as the preparation may otherwise dry out quickly and no longer be able to be applied properly. Once dried, Verrumal Solution cannot be used anymore. Apart from this, the solution must no longer be used if crystals have formed.

Make sure that the Verrumal Solution does not come into contact with textiles or acrylic (e.g. acrylic baths) when applying, as the solution may cause stains that cannot be removed (before the coating is formed).

Dimethyl sulfoxide may cause skin irritation.

This medicine contains 160 mg of alcohol (ethanol) in each gram. It may cause burning sensation on damaged skin

Fire warning: Do not light a cigarette or stay near open flames until the film is completely dry.

Effects on Driving

4.7 Effects on ability to drive and use machines

Verrumal Solution has no or only negligible effect on the ability to drive and use machines.